|Articles taken from the MARCH 2005 Huntington's News. The Quarterly Newsletter of the Huntington's Disease Associations of New Zealand|
HUNTINGTONS DISEASE RESEARCH SYMPOSIUM
Presented by Huntingtons Research Group Victoria and Australian
Huntingtons Disease Association (Victoria) on 2nd December 2004
Activity levels and age of onset in Huntingtons Disease
In Huntingtons disease (HD) the only proven factor to be related to onset age is the CAG repeat number, with longer repeat lengths associated with earlier average age of onset.
Nevertheless, this only explains 5O-73% of the variation observed. An HD mouse model provides evidence for the protective effects of environmental stimulation. The aim of the present study was to identify and measure a series of environmental factors, including physical, intellectual and passive activity, occupation and education, to determine if they modify the age of symptom onset in HD.
Thirty participants with HD and a significant other completed two retrospective questionnaires. Diversity, intensity and percentage intensity of activities were calculated and linear regressions and ANCOVAs were used to investigate the correlation between these activity variables and age of onset while taking into account the effect of the CAG repeat length.
There was a significant negative correlation between passive percentage intensity of activity and age of onset in the teen years (partial correlation -O.615,R2=O.562,p=0.011), and in the early adulthood years (partial correlation -O.503,R2=O.399,p=O.047) This indicates that individuals who participated in high levels of passive activity presented with symptoms at a significantly earlier age than those with low passive activity (F(1,15)=7.162,p=O.018. Observed trends for physical and intellectual activity indicated that higher activity was associated with later onset although statistical significance was not reached.
This is the first direct evidence in humans that environmental factors are associated with timing of disease onset in HD and provides a potential intervention for those at risk. Important future studies based on this data include a retrospective study of a larger cohort and the implementation of a longitudinal prospective study of pre-morbid activity levels.
Zoe Horton1, Veronica Collins1, Ros Tassicker2, Andrew Churchyard3 and Martin Delatycki 1, 2
1 Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Victoria
2 Genetic Health Services Victoria
3 Huntingtons Disease clinics, Bethlehem and St Georges Hospitals, Victoria
Acknowledgement: Australian Huntingtons Disease Association (QLD) Inc February 2005